Published Work

32. Y.-I. Chen, Y.-J. Chang, S.-C. Liao, T. D. Nguyen, J. Yang, Y.-A. Kuo, S. Hong, Y.-L. Liu, H. G. Rylander, S. R. Santacruz, T. E. Yankeelov, H.-C. Yeh, "Generative Adversarial Network Enables Rapid and Robust Fluorescence Lifetime Image Analysis in Live Cells," Communications Biology 5, 18, 2022.

31. Y.-L. Liu, C.-C. Yen, T.-S. T. Liu, C.-H. Chang, T. T.-F. Shih, J.-H. Wang, M.-C. Yang, F.-H. Lin, H.-C. Liu*, "Safety and Efficacy of Kartigen® in Treating Cartilage Defects: A Randomized, Controlled, Phase I Trial," Polymers 13(18): 3029, 2021.

30. M. Kim, S. Hong, T. E. Yankeelov, H.-C. Yeh*, Y.-L. Liu*, “Deep Learning-Based Classification of Breast Cancer Cells Using Transmembrane Receptor,” Bioinformatics, btab581, 2021.

29. H.-C. Liu, T.-S. T. Liu, Y.-L. Liu, J.-H. Wang, C.-H. Chang, T. T.-F. Shih, F.-H. Lin*, "Atelocollagen-Embedded Chondrocyte Precursors as a Treatment for Grade-4 Cartilage Defects of the Femoral Condyle: A Case Series with up to 9-Year Follow-Up."Biomolecules 11(7): 942, 2021.

28. M. Kim, Y.-L. Liu* "Transmembrane Receptor Dynamics as Biophysical Markers for Assessing Cancer Cells," In: Santra T.S., Tseng FG. (eds) Handbook of Single Cell Technologies. Springer, 2021.

27. Y.-L. Liu*, E. P. Perillo, P. Ang, M. Kim, D. T. Nguyen, K. Blocher, Y.-A. Chen, C. Liu, A. M. Hassan, H. T. Vu, A. K. Dunn, and H.-C. Yeh*, "Development of three-dimensional two-color dual-particle tracking microscope and its applications in monitoring DNA conformational changes and antibody-conjugated nanoparticle landings on the plasma membrane," ACS Nano 14(7): 7927-7939, 2020.

26. C.-K. Chiou, Y.-L. Liu (co-first), P.-J. Huang, P.-H. Tsou, C.-T Chen, H.-H. Lee, Y.-N. Wang, J.L. Hsu, J.-F. Lee, T.E. Yankeelov, J. Kameoka*, H.-C. Yeh*, and M.-C. Hung*, "Digital receptor occupancy assay in quantifying on- and off-target binding affinities of therapeutic antibodies," ACS Sensors 5(2): 296-302, 2020.

25. X. Peng, X. Liu, Y.-L. Liu, J. Y. Kim, Y.-I. Chen, P. Ang, A. Nguyen, J. Leal, H.-C. Yeh, and D. Ghosh*, "Brain-penetrating peptide shuttles through the blood-brain barrier and extracellular-like space," ChemRxiv. Preprint, 2019.

24. Y.-L. Liu, A.M. Horning (co-first), B. Lieberman, M. Kim, C.-K. Lin, C.-N. Hung, C.-W. Chou, C.-M. Wang, C.-L Lin, N.B. Kirma, M.A. Liss, R. Vasisht, E.P. Perillo, K. Blocher, H. Horng, J.A. Taverna, J. Ruan, T.E. Yankeelov, A.K. Dunn, T. H.-M. Huang, H.-C. Yeh*, and C.-L. Chen*, "Spatial EGFR dynamics and metastatic phenotypes modulated by upregulated EphB2 and Src pathways in advanced prostate cancer," Cancers 11(12), 1910, 2019.

23. Y.-I. Chen, Y.-J. Chang, T.D. Nguyen, C. Liu, S. Phillion, Y.-A. Kuo, H.T. Vu, A. Liu, Y.-L. Liu, S. Hong, and H.-C. Yeh, "Measuring DNA hybridization kinetics in live cells using a time-resolved 3D single-molecule tracking method," Journal of the American Chemical Society 141(40): 15747-15750, 2019.

22. Y.-L. Liu, C.-K. Chou; M. Kim, R. Vasisht, Y.-A. Kuo, C. Liu, E.P. Perillo, Y.-A. Chen, K. Blocher, H. Horng, Y.-I Chen, D. T. Nguyen, T. E. Yankeelov, M.-C. Hung, A. K. Dunn, and H.-C. Yeh*, "Assessing metastatic potential of breast cancer cells based on EGFR dynamics," Scientific Reports 9, 3395, 2019.

21. A. M. Hassan, X. Wu, J. W. Jarrett, S. Xu, J. Yu, D. R. Miller, E. P. Perillo, Y.-L. Liu, D. T. Chiu, H.-C. Yeh*, and A. K. Dunn*, "Polymer dots enable deep in vivo multiphoton fluorescence imaging of microvasculature," Biomedical Optics Express 10(2): 584-599, 2019.

20. Y.-A. Chen, H.T. Vu, Y.-L. Liu, Y.-I Chen, T.D. Nguyen, Y.-A. Kuo, S. Hong, Y.-A. Chen, S. Carnahan, J. T. Petty, and H.-C. Yeh*, "Improving NanoCluster Beacon performance by blocking the unlabeled NC probes," Chemical Communications 55, 462-465, 2019.

19. C.-K. Chou, P.-J. Huang, P.-H. Tsou, Y. Wei, H.-H. Lee, Y.-N. Wang, Y.-L. Liu, C. Shi, H.-C. Yeh, J. Kameoka, and M.-C. Hung*, "A flow-proteometric platform for analyzing protein concentration (FAP): Proof of concept for quantification of PD-L1 protein in cells and tissues," Bioelectronics and Biosensors 117, 97-103, 2018.

18. V. Le, J. Lee, S. Chaterji, A. Spencer, Y.-L. Liu, P. Kim, H.-C. Yeh, D.-H. Kim and A. B. Baker*, "Syndecan-1 in mechanosensing of nanotopological cues in engineered materials," Biomaterials 155, 13-24, 2018.

17. A. M. Hassan, X. Wu, J. W. Jarrett, S. Xu, D. R. Miller, J. Yu, E. P. Perillo, Y.-L. Liu, D. T. Chiu, H.-C. Yeh*, and A.K. Dunn* "Polymer dots enable deep in vivo multiphoton fluorescence imaging of cerebrovascular architecture," SPIE Proceedings, 104982Y, 2018.

16. C.-W. Li, S.-O. Lim, E.M. Chung, Y.-S. Kim, A.H. Park, J.-H. Cha, W. Xia, L.-C. Chan, T. Kim, S.-S. Chang, H.-H. Lee, C.-K. Chou, Y.-L. Liu, H.-C. Yeh, E.P. Perillo, A.K. Dunn, C.-W. Kuo, K.-H. Khoo, J.L. Hsu, Y. Wu, J.-M. Hsu, H. Yamaguchi, J. Yao, A.A. Sahin, G.N. Hortobagyi, S.S. Yoo and M.-C. Hung*, "Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1," Cancer Cell 33(2): 187-201, 2018.

15. E. P. Perillo, J. W. Jarrett, Y.-L. Liu, A. Hassan, D. C. Fernée, J. R. Goldak, A. Bonteanu, D. J. Spence, H.-C. Yeh, and A. K. Dunn*, "Two-color multiphoton in vivo imaging with a femtosecond diamond Raman laser," Light: Sciences & Applications 6, e17095, 2017.

14. J. M. Obliosca, S. Y. Cheng, Y.-A. Chen, M. F. Llanos, Y.-L. Liu, D. M. Imphean, D. Bell, J. T. Petty, P. Ren, and H.-C. Yeh*, "LNA thymidine monomer enables differentiation of the four single-nucleotide variants by melting temperature," Journal of the American Chemical Society 139(20): 7110-7116, 2017.

13. C. Liu, J.M. Obliosca, Y.-L. Liu, Y.-A. Chen, N. Jiang, and H.-C. Yeh*, "3D single-molecule tracking enables direct hybridization kinetics measurement in solution," Nanoscale 9: 5664-5670, 2017.

12. Y.-L. Liu, E.P. Perillo, C. Liu, P. Yu, C.-K. Chou, M.-C. Hung, A.K. Dunn, and H.-C. Yeh*, "Segmentation of 3D trajectories acquired by TSUNAMI microscope: an application to EGFR trafficking," Biophysical Journal 111(10): 2214-2227, 2016.

11. C.-C Wang, K.-C. Yang, K.-H. Lin, Y.-L. Liu, Y.-T. Yang, T.-F. Kuo, and I.-H. Chen, "Expandable Scaffold Improves Integration of Tissue-Engineered Cartilage: An In Vivo Study in a Rabbit Model," Tissue Engineering Part A 22 (11-12), 873-884, 2016

10. C. Liu, Y.-L. Liu, E. P. Perillo, A. K. Dunn , and H.-C. Yeh, "Single-molecule tracking and its application in biomolecular detection," IEEE Journal of Selected Topics in Quantum Electronics 22(4): 6804013, 2016.

9. C. Liu, Y.-L. Liu (co-first), E.P. Perillo, N. Jiang, A.K. Dunn, and H.-C. Yeh*, "Improving z-tracking accuracy in the two-photon single-particle tracking microscope," Applied Physics Letters 107, 153701, 2015.

8. Y.-A. Chen, J. M. Obliosca, Y.-L. Liu, C. Liu, M. L. Gwozdz, and H.-C. Yeh, "NanoCluster Beacons enable detection of a single N6-methyladenine," Journal of the American Chemical Society 137(33): 10476-10479, 2015.

7. E. P. Perillo, Y.-L. Liu, K. Huynh, C. Liu, C.-K. Chou, M.-C. Hung, H.-C. Yeh*, and A. K. Dunn*, "Deep and high-resolution three-dimensional tracking of single particles using nonlinear and multiplexed illumination," Nature Communications 6, 7874, 2015.

6. S. Juul, J.M. Obliosca (equal contribution), C. Liu, Y.-L. Liu, Y.-A. Chen, D.M. Imphean, B. R. Knudsen, Y.-P. Ho, K.W. Leong, and H.-C. Yeh, "NanoCluster Beacons as reporter probes in rolling circle enhanced enzyme activity detection," Nanoscale 7, 8332-8337, 2015.

5. E. Perillo, Y.-L. Liu, C. Liu, H.-C. Yeh, and A.K. Dunn*, "Single-particle tracking through highly scattering media with multiplexed two-photon excitation," SPIE Proceedings 933107, 2015.

4. J. M. Obliosca, M. C. Babin, C. Liu, Y.-L. Liu, Y.-A. Chen, R. A. Batson, M. Ganguly, J. T. Petty, and H.-C. Yeh, "A complementary palette of NanoCluster Beacons," ACS Nano 8(10): 10150-10160, 2014.

3. C.-C. Wang, K.-C. Yang, K.-H. Lin, C.-C. Wu, Y.-L. Liu, F.-H. Lin, and I.-H. Chen, “A biomimetic honeycomb-like scaffold prepared by flow-focusing technology for cartilage regeneration,” Biotechnology and Bioengineering 111 (11), 2338-2348, 2014.

2. T.-Y. Ling, Y.-L. Liu, C.-C. Ho, P.-N. Tsao, Y.-C. Tung, Y.-K. Huang, H.-K. Chen, H.-W. Chen, C.-H. Cheng, K.-H. Lin, and F.-H. Lin*, “Lung stem/progenitor cells induce angiogenesis and differentiation into alveolar pneumocytes in a three-dimensional gelatin microbubble-scaffold,” Biomaterials 35 (22), 5660-5669, 2014.

1. C.-C. Wang, K.-C. Yang, K.-H. Lin, Y.-L. Liu, H.-C. Liu, and F.-H. Lin*, “Cartilage regeneration in SCID mice using a highly organized three-dimensional alginate scaffold,” Biomaterials 33 (1), 120-127, 2012.